Buy Ziprasidone (Geodon) online

Buy Geodon (Ziprasidone Hydrochloride) atypical antipsychotic
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GEODON: NONCLINICAL TOXICOLOGY

Carcinogenesis, Mutagenesis, Impairment of Fertility

Carcinogenesis

Lifetime carcinogenicity studies were conducted with ziprasidone in Long Evans rats and CD-1 mice. Ziprasidone (Geodon) was administered for 24 months in the diet at doses of 2, 6, or 12 mg / kg per day to rats, and 50, 100, or 200 mg / kg per day to mice (0.1 to 0.6 and 1 to 5 times the maximum recommended human dose [MRHD] of 200 mg / day on a mg / m2 basis, respectively). In the rat study, there was no evidence of an increased incidence of tumors compared to controls. In male mice, there was no increase in incidence of tumors relative to controls. In female mice, there were dose-related increases in the incidences of pituitary gland adenoma and carcinoma, and mammary gland adenocarcinoma at all doses tested (50 to 200 mg / kg per day or 1 to 5 times the MRHD on a mg / m2 basis). Proliferative changes in the pituitary and mammary glands of rodents have been observed following chronic administration of other antipsychotic agents and are considered to be prolactin-mediated. Increases in serum prolactin were observed in a 1-month dietary study in female, but not male, mice at 100 and 200 mg / kg per day (or 2.5 and 5 times the MRHD on a mg / m2 basis). Ziprasidone had no effect on serum prolactin in rats in a 5-week dietary study at the doses that were used in the carcinogenicity study. The relevance for human risk of the findings of prolactin-mediated endocrine tumors in rodents is unknown.

Mutagenesis

Geodon (Ziprasidone) was tested in the Ames bacterial mutation assay, the in vitro mammalian cell gene mutation mouse lymphoma assay, the in vitro chromosomal aberration assay in human lymphocytes, and the in vivo chromosomal aberration assay in mouse bone marrow. There was a reproducible mutagenic response in the Ames assay in one strain of S. typhimurium in the absence of metabolic activation. Positive results were obtained in both the in vitro mammalian cell gene mutation assay and the in vitro chromosomal aberration assay in human lymphocytes.

Impairment of Fertility

Geodon (Ziprasidone) was shown to increase time to copulation in Sprague-Dawley rats in two fertility and early embryonic development studies at doses of 10 to 160 mg / kg per day (0.5 to 8 times the MRHD of 200 mg / day on a mg / m2 basis). Fertility rate was reduced at 160 mg / kg per day (8 times the MRHD on a mg / m2 basis). There was no effect on fertility at 40 mg / kg per day (2 times the MRHD on a mg / m2 basis). The effect on fertility appeared to be in the female since fertility was not impaired when males given 160 mg / kg per day (8 times the MRHD on a mg / m2 basis) were mated with untreated females. In a 6-month study in male rats given 200 mg / kg per day (10 times the MRHD on a mg / m2 basis) there were no treatment-related findings observed in the testes.

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